significant activity against leukemia cancer cell lines ccrfcem (ATCC)
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significant activity against leukemia cancer cell lines ccrfcem
Significant Activity Against Leukemia Cancer Cell Lines Ccrfcem, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 178 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/significant+activity+against+leukemia+cancer+cell+lines+ccrfcem/CCRF-CEM/pm33676043-66-3-22
Average 95 stars, based on 178 article reviews
Significant Activity Against Leukemia Cancer Cell Lines Ccrfcem, supplied by ATCC, used in various techniques. Bioz Stars score: 95/100, based on 178 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/significant+activity+against+leukemia+cancer+cell+lines+ccrfcem/CCRF-CEM/pm33676043-66-3-22
Average 95 stars, based on 178 article reviews
significant activity against leukemia cancer cell lines ccrfcem - by Bioz Stars,
2026-10
95/100 stars
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Activity Assay:Article Title: 3,7-bis-benzylidene hydrazide ciprofloxacin derivatives as promising antiproliferative dual TOP I & TOP II isomerases inhibitors. Article Snippet: We report herein design and synthesis of a new series of 3,7-bis-benzylidenes of ciprofloxacin.. Most of the target compounds revealed good cytotoxic activity; the most potent 4e and 4i achieved strong broad spectrum antiproliferative activity with comparable activity to Doxorubicin with IC50 (μM) of 1.21 ± 0.02, 0.87 ± 0.04, 1.21 ± 0.02; 0.41 ± 0.02, 0.57 ± 0.06, 1.31 ± 0.04 and 1.26 ± 0.01, 1.79 ± 0.04, 0.63 ± 0.01 against leukemia cancer cell line HL-60 (TB), colon cancer cell line HCT-116 and breast cancer cell line MCF7, respectively.. Moreover, the most potent derivative 4i induced apoptosis at G2/M phase Investigating the mechanism of action of compounds 4e, 4 h and 4i exhibited promising dual TOP Iα and TOP IIB % inhibition comparable to Camptothecin and Etoposide; respectively. Multiple Displacement Amplification:Article Title: 3,7-bis-benzylidene hydrazide ciprofloxacin derivatives as promising antiproliferative dual TOP I & TOP II isomerases inhibitors. Article Snippet: We report herein design and synthesis of a new series of 3,7-bis-benzylidenes of ciprofloxacin.. Most of the target compounds revealed good cytotoxic activity; the most potent 4e and 4i achieved strong broad spectrum antiproliferative activity with comparable activity to Doxorubicin with IC50 (μM) of 1.21 ± 0.02, 0.87 ± 0.04, 1.21 ± 0.02; 0.41 ± 0.02, 0.57 ± 0.06, 1.31 ± 0.04 and 1.26 ± 0.01, 1.79 ± 0.04, 0.63 ± 0.01 against leukemia cancer cell line HL-60 (TB), colon cancer cell line HCT-116 and breast cancer cell line MCF7, respectively.. Moreover, the most potent derivative 4i induced apoptosis at G2/M phase Investigating the mechanism of action of compounds 4e, 4 h and 4i exhibited promising dual TOP Iα and TOP IIB % inhibition comparable to Camptothecin and Etoposide; respectively. |